Isla Santa María Vacations from $604

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Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. Post Office Bay is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Galapagos Coliving Ecuador Casa Tuna

Galapagos Coliving Ecuador Casa Tuna

3 out of 5
Price was $804, price is now $604 per person
$604
per person
Mar 9 - Mar 14
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
No reviews
Galapagos Native

Galapagos Native

3 out of 5
Save 100% on your flight
Price was $1,238, price is now $656 per person
$656
per person
Mar 9 - Mar 14
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
7.8/10 Good! (93 reviews)
Confortablenstop over for a family

Reviewed on Dec 28, 2024

Blu Galapagos Sustainable Waterfront Lodge

Blu Galapagos Sustainable Waterfront Lodge

4 out of 5
Price was $1,201, price is now $894 per person
$894
per person
Mar 9 - Mar 14
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
8.8/10 Excellent! (121 reviews)
Room was spotless & well kept. The restaurant staff & housekeeping/groundskeeping staff were lovely people and so kind to us. We loved being so close to town, being able to use the bikes and paddle boards at the hotel, loved the little vibe of the property itself -- and that the iguanas, lizards and sea lions were usually hanging around on the dock made for endless entertainment. We had the best stay on Santa Cruz. Thanks for everything, we hope to be back soon.

Reviewed on Jan 22, 2026

El Barranco Galapagos

El Barranco Galapagos

2.5 out of 5
Price was $1,240, price is now $971 per person
$971
per person
Mar 9 - Mar 14
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.6/10 Exceptional! (22 reviews)
Great location, nice sea view on balcony, rooms clean and spacious. Breakfast was good especially the omelette

Reviewed on Jan 15, 2026

Angermeyer Waterfront Inn

Angermeyer Waterfront Inn

3.5 out of 5
Price was $1,017, price is now $804 per person
$804
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.4/10 Exceptional! (122 reviews)
Staff very friendly and helpful. Comfortable room.

Reviewed on Jan 16, 2026

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Discover the most popular places to visit in Isla Santa María

Swimming with sea turtles was one of the many amazing moments of my Galapagos adventure. Like most of the other animals, they went about their business without seeming to even notice the people around.

Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting.

Post Office Bay
I've been spotted! A family of marine iguanas auditioning for meerkat manor #LifeAtExpedia

Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area.

Punta Suarez

What to do in Isla Santa María

Learn about the history of Floreana

Full Day Floreana Tour

$220
per adult
Full Day Floreana Tour
Galapagos Enchanting 3 Islands

Galapagos Enchanting 3 Islands (5 Days)

$1,329
per adult
Galapagos Enchanting 3 Islands (5 Days)
Faune seeing at the snorkeling

Full Day Santa Fe Playa escondida snorkeling tour

$220
per adult
Full Day Santa Fe Playa escondida snorkeling tour
See all activities in Isla Santa María

Isla Santa María Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $155 total per night from Feb 2 to Feb 3
$155 total
Feb 2 - Feb 3
9/10 Wonderful! (389 reviews)
very pretty but rooms are small

Reviewed on Jan 28, 2026

Hotel Fiesta
Ikala Galapagos Hotel

Ikala Galapagos Hotel

4 out of 5
Tomas de Berlanga 110 y Moises Brito Puerto Ayora Ecuador
$221 nightly
The price is $243 total per night from Feb 6 to Feb 7
$243 total
Feb 6 - Feb 7
9.6/10 Exceptional! (131 reviews)
Gorgeous property and wonderful staff!

Reviewed on Jan 24, 2026

Ikala Galapagos Hotel
Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$126 nightly
The price is $126 total per night from Feb 5 to Feb 6
$126 total
Feb 5 - Feb 6
9.8/10 Exceptional! (109 reviews)
Great place! Incredibly friendly and kind staff.

Reviewed on Jan 8, 2026

Maidith Galapagos Inn
See all 211 properties in Isla Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Isla Santa María Vacation Packages

Isla Santa Marían Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

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Frequently asked questions

How much does an Isla Santa María vacation package cost?
You can grab a vacation package to this top destination from $604 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Isla Santa María?
January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.
How many days is enough for Isla Santa María?
The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.
How to find the best Isla Santa María package deals?
Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.
Is it cheaper to book an Isla Santa María vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Isla Santa María?
If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.
How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?
If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.